| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 13/03/25 18.45 | Athletic Bilbao | Roma | 3:1 |
| 13/03/25 18.45 | Lazio | Viktoria Pilsen | 1:1 |
| 13/03/25 18.45 | Olympiacos Pireo | FK Bodö/Glimt | 2:1 |
| 13/03/25 18.45 | Eintracht Francoforte | Ajax Amsterdam | 4:1 |
| 13/03/25 21.00 | Tottenham Hotspur | AZ Alkmaar | 3:1 |
| 13/03/25 21.00 | Manchester United | Real Sociedad | 4:1 |
| 13/03/25 21.00 | Olympique Lione | FCSB Bukarest | 4:0 |
| 13/03/25 21.00 | Glasgow Rangers | Fenerbahce Istanbul | 3:4d.c.r |