| Data | In casa | Ospite | Risultato |
|---|---|---|---|
| 28/11/24 18.45 | Lazio | PFC Ludogorets Razgrad | -:- |
| 28/11/24 18.45 | Dynamo Kiev | Viktoria Pilsen | -:- |
| 28/11/24 18.45 | Qarabag | Olympique Lione | -:- |
| 28/11/24 18.45 | Besiktas Istanbul | Maccabi Tel Aviv | -:- |
| 28/11/24 18.45 | Rigas Futbola Skola | PAOK Salonicco | -:- |
| 28/11/24 18.45 | RSC Anderlecht | FC Porto | -:- |
| 28/11/24 18.45 | Athletic Bilbao | IF Elfsborg Boras | -:- |
| 28/11/24 18.45 | AZ Alkmaar | Galatasaray Istanbul | -:- |
| 28/11/24 21.00 | Slavia Praga | Fenerbahce Istanbul | -:- |
| 28/11/24 21.00 | Manchester United | FK Bodö/Glimt | -:- |
| 28/11/24 21.00 | Tottenham Hotspur | Roma | -:- |
| 28/11/24 21.00 | Ferencvaros Budapest | Malmö FF | -:- |
| 28/11/24 21.00 | Sporting Braga | 1899 Hoffenheim | -:- |
| 28/11/24 21.00 | Real Sociedad | Ajax Amsterdam | -:- |
| 28/11/24 21.00 | FC Midtjylland | Eintracht Francoforte | -:- |
| 28/11/24 21.00 | FCSB Bukarest | Olympiacos Pireo | -:- |
| 28/11/24 21.00 | OGC Nizza | Glasgow Rangers | -:- |
| 28/11/24 21.00 | FC Twente Enschede | Royale Union Saint-Gilloise | -:- |